Learning Objectives:

• Review how the LUT is susceptible to the negative effects of age
• Describe the impact of oxidative injury on age-related LUT disorders
• Discuss strategies to correct/reverse age-related bladder dysfunction

While there are several pharmacologic or cell-based strategies that show promise for slowing progression of several age-associated LUT disorders, most simply ‘mask’ the symptoms but do not reverse the condition or restore healthy form and function. This lecture will highlight evidence that increased reactive oxygen species (ROS) and associated oxidative stress are a defining cause in a growing number of age associated LUT disorders. Emerging evidence suggests that alterations in levels of the enzyme purine nucleoside phosphorylase (PNPase) may reflect the extent of cell damage. Given the fundamental role of oxidative stress in the pathogenesis of many age-associated disorders, PNPase inhibitors has translational potential for treating age-associated LUT dysfunctions and resultant syndromes in humans.

Why is this topic important?
Given the important fundamental role for oxidative stress and mitochondrial dysregulation in the pathogenesis of many LUT disorders including those age-related; therapies that can protect and restore mitochondrial function are important in terms of disease prevention.

Recommended readings ahead of this lecture: https://doi.org/10.1172/jci.insight.140109.

Why ICS is important for Applied Scientists / Researchers
The ICS is a unique forum that promotes interactions and networking amongst investigators, clinicians and industry attendees that is invaluable in establishing collaborations and stimulating innovation.

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