Investigation of Lower Urinary System Symptoms in Children with Cerebral Palsy According to Gross Motor Function Classification System

UNAL B1, PISIRICI P2, KOSEOGLU KURT A1, TUGTEPE H3

Research Type

Clinical

Abstract Category

Paediatrics

Abstract 399
Open Discussion ePosters
Scientific Open Discussion Session 102
Wednesday 23rd October 2024
13:05 - 13:10 (ePoster Station 2)
Exhibition Hall
Incontinence Motor Dysfunction Pediatrics
1. Bahcesehir University, Graduate Education Institute, Physiotherapy and Rehabilitation Department, Istanbul, Türkiye, 2. Bahcesehir University, Health Science Faculty, Physiotherapy and Rehabilitation Department, Istanbul, Turkey, 3. Private Tugtepe Pediatric Urology Center, Division of Bladder and Bowel Dysfunction, İstanbul, Turkey
Presenter
Links

Poster

Abstract

Hypothesis / aims of study
Neurological defects in children with cerebral palsy (CP) not only affect their motor skills but also lead to bladder and bowel problems. Although most children with CP have achieved urinary control, more than 50% of cases experience lower urinary tract symptoms (LUTS), leading them to seek medical attention at pediatric urology clinics due to urinary dysfunction. Common LUTS complaints observed in CP include delayed toilet training, urinary incontinence, increased frequency of urination, urgency, urinary hesitancy, and recurrent urinary tract infections. The symptoms seriously reduce the quality of life of children. LUTS is among the most common reasons for hospitalization in adulthood for individuals with CP. Therefore, it is extremely important to detect LUTS in CP at an early age, to create appropriate treatment programs and to protect the upper urinary systems.
 The aim of this study is to determine the severity of LUTS, which is common in children with CP; It is examined according to quality of life, toilet training age, CP type and gross motor functional classification system (GMFCS).
Study design, materials and methods
54 (29 girls; 25 boys) children with CP were included in the study. 
Urinary symptoms of the children included in the study evaluated with the Voiding Disorders Symptom Score (DVISS), 
Quality of life of the children included in the study evaluated with the Pediatric Incontinence Quality of Life Scale (PINQ).
Evaluated from bladder diary data (bladder usage capacity, frequency of voiding )
It was examined how children's urinary symptoms,  quality of life and toilet trainiing age  differ according to the type of CP and GMFCS.
Inclusion Criteria;
5-18 years old
Diagnosed with cerebral palsy
Lower urinary tract complaints and symptoms
Children in levels I-II-III or IV according to the GMFCS were included in the study.
Exclusion criteria;
At level V according to the GMFCS
Epileptic seizures
Cognitively impaired 
Children with anatomical or congenital malformations of the urinary system were not included in the study.
Results
According to the CP type  results were as follows;

The IBSS scores for hemiplegic (HP) , diplegic(DP) , quadriplegic (QP) and ataxic(AT)  CP were as follows, respectively: (HP:13, DP:15,32 , QP:16, AT:13,17), p=0,145
The PINQ scores for HP, DP, QP and AT  CP were as follows, respectively: (HP: 30,62, DP: 32,03, QP: 33,5, AT: 29,17), p=0,462
The toilet training age  for HP, DP, QP and AT  CP were as follows, respectively: (HP: 4,12, DP: 5,21, QP: 9,25,5, AT: 5,17), p=0,001

According to the GMFCS level  results were as follows;

The IBSS scores for according to GMFCS level I-II-III-IV  were as follows, respectively;
(Level-I: 13,63, Level-II:16,5, Level-III: 14,77, Level-IV: 18,2), p=0,075

The PIN-Q scores for according to GMFCS level I-II-III-IV  were as follows, respectively;
(Level-I: 31,38, Level-II:31,5, Level-III: 30,62, Level-IV: 34,4), p=0,677

The toilet training age for according to GMFCS level I-II-III-IV  were as follows, respectively;
(Level-I: 4,73, Level-II:5,46, Level-III: 5,63, Level-IV: 7,46), p=0,002
Interpretation of results
In the literature, studies examining the urinary symptoms of children with CP were generally conducted at all levels (I-II-III-IV-V) according to GMFCS, and children with cognitive impairment were not excluded. Since voluntary urination is an action that requires mobilization and cognitive control together, these two factors should be taken into consideration when evaluating LUTS in children with CP. 
In the literature, in studies where all levels of GMFCS are included; It has been observed that as the GMFCS level increases, the quality of life decreases (1) and symptoms increase (2). In our study, in children with CP who had GMFS scores between I and IV and did not have cognitive impairment; There is no statistical significance between CP type and quality of life, symptoms, and bladder use capacity.  
In the literature, in a study conducted in GMFCS I-V groups, it was found that quadriplegic type CP was the slowest to gain continence (3). In our study, consistent with the literature, toilet training age was found to be statistically significant only in the level IV and quadriplegic groups. As the GMFCS level increases, the age of toilet training is delayed.
Concluding message
In our study, consistent with the literature, toilet training age was found to be statistically significant only in the level IV and quadriplegic groups. As the GMFCS level increases, the age of toilet training is delayed.
Since voluntary urination is an action that requires mobilization and cognitive control together, we recommend that the GMFCS V group should not be included or evaluated separately when evaluating LUTS in children with CP.
References
  1. Yildiz, N., Akkoç, Y., Ersöz, M., Gündüz, B., Erhan, B., Yesil, H., . . . Alkan, H. (2017). Cross-sectional study of urinary problems in adults with cerebral palsy: awareness and impact on the quality of life. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, s. 38(7), 1193–1203
  2. Bross, S., Honeck, P., Kwon, S. T., Badawi, J. K., Trojan, L., & Alken, P. (2007). Correlation between motor function and lower urinary tract dysfunction in patients with infantile cerebral palsy. Neurourology and urodynamics, s. 26(2), 222–227.
  3. Roijen, L. E., Postema, K., Limbeek, V. J., & Kuppevelt, V. H. (2001). Development of bladder control in children and adolescents with cerebral palsy. Developmental medicine and child neurology, s. 43(2), 103–107
Disclosures
Funding No grant or support has been received from any institution or person. Clinical Trial Yes Registration Number NIH (National Library of Medicine), NCT05351138 RCT No Subjects Human Ethics Committee Bahçesehir University Non-invasive Clinical Research Ethics Committee Helsinki Yes Informed Consent Yes
25/04/2025 09:27:07