Hypothesis / aims of study
Prostate cancer has a very high prevalence, it is the most frequent neoplasia in male, and it is considered the second cause of cancer mortality in men. In recent years, the consequences of its management on the quality of life. For this reason, it is very important to investigate the factors that improve their management.
Prostate cancer is one of the most frequent oncological pathologies in men in terms of incidence and prevalence, both in the world and in Spain (1). With a incidence in our country of 70 cases per 100,000 inhabitants, the average age at which It is diagnosed at 69 years of age and usually in an asymptomatic stage (2). It is the most diagnosed tumor in men in developed countries and the fifth
cause of cancer death in men worldwide (3).
To determine the impact of the use of MRI on the efficacy of robotic radical prostatectomy (RRP) in the treatment of prostate cancer and the relationship with subsequent symptoms.
Study design, materials and methods
Prospective multicenter sample of, 1136 operated patients. Groups: GS (success: n= 982): Patients cured by RRP; GR (residual or recurrence, n= 154): no cure. Variables: Age. Magnetic resonance performed and findings, prostatic antigen (PSA), evolution time between biopsy and PRR, positive cylinders in the biopsy, T stage, Gleason, functional results, sexual life before and after treatment, erectile dysfunction treatment, urinary incontinence.
Descriptive statistics, ANOVA analysis, Student's t test, Fisher's exact test, and multivariate multiple regression analysis.
The analysis will be performed using the automatic statistical calculator IBM SPSS Statistics for Windows, Version 25.0. Statistical significance was accepted for p<0.05.
Results
Average age 63.37 years, without differences. Magnetic resonance performed in 56.72%, more in group GR (98.70%). Mean PSA 7.83, higher in GR. PIRADS <3 13.64%, more in GS (15.48%); PIRADS 3 in 5.11% without differences; PIRADS 4-5 in 28.08% without differences, GR greater absence of sexual life pre-treatment 53.26% (p=0.02) and post-treatment 79.84 (p-value=0.01). Erectile dysfunction treatment with higher PDE5i in GS (p-value=<0.01), PIRADS lower than 3 in GS was associated with less success (Relative Risk 0.0008) and with more recurrence in GR (RR6.185). In PIRADS 3 there was a longer evolution time between biopsy and PRR. PIRADS 5 was related to more positive cylinders, more T3 in MRI, more pT2b, more Gleason (4+5), more severe post-surgical urinary incontinence, shorter time between biopsy and robotic radical prostatectomy.
Interpretation of results
Sexual dysfunction and urinary incontinence are frequent symptoms in prostate cancer, PIRADS characterization of nuclear magnetic resonance influences the management of prostate cancer.