Hypothesis / aims of study
Neurogenic bladder associated with spina bifida disease remains a major cause for mortality or morbidity due to kidney damages.
However, we currently do not know which urodynamic findings are associated with an higher risk of upper tract damages (UUTD) in spina bifida patients. The objective of the present study was to evaluate urodynamic findings associated with functional kidney failure and/or with morphological kidney damages.
The objective of the present study was to evaluate urodynamics findings associated with UUTD.
Study design, materials and methods
A large single-center restrospective study was conducted in our national referral center for spina bifida patients using our patients’ files. All urodynamics curves were assessed by the same examinator. Functional and/or morphological evaluation of the upper urinary tract were done at the same moment as the urodynamic exam (between 1 week before and 1 month after). Kidney function was assessed using creatinine serum levels or 24 hours urinary creatinine levels (creatinine clearance) for walking patients, or with the 24h urinary creatinine level for wheelchair‐users.
Interpretation of results
In this large series of spina bifida patients, maximum detrusor pressure and bladder compliance are the main urodynamic findings determinants of UUTD risk and patients’ with those factors needs to be closely followed up.