Our study cohort involved 165 women, median (IQR) age 53 (40-66) years, BMI 27 (23-29); 103 (62%) Caucasian. Forty-six (28%) had a history of smoking, 20 (12%) had diabetes, 71 (43%) had cardiovascular comorbidities, 102 (62%) had a history of neuropsychiatric disorder and 85 (53%) had a history of pregnancy with vaginal delivery.
In 117 patients, median CCFI score was 5 (0-13) and ODS was 10 (6-14). There was a significant correlation between increasing CCFI score and both decreased PMI (coefficient: 1.069, p = 0.02), and increased eLASV (coefficient: 0.053 p = 0.03). There was no correlation ODS score and PMI (p = 0.07) or eLASV (p = 0.94).
The median (IQR) for resting H line was 5.7 (5.1-6.4), resting M line 1.6 (1.1-2.3), levator hiatus width 3.75 (3.2-4.3), and eLASV 23.301 (11.278-33.357). Fifty-seven women (35%) had abnormal hiatus length with an H line >6 cm, 60 (36%) had abnormal hiatus descent, or M line >2 cm at rest, and 28 (17%) had abnormal basin volume with an eLASV >38.5. There was a significant correlation between advancing age and increasing H line, M line, and eLASV (p<0.001).
Linear regression analysis indicated that decreased PMI was significantly associated with increased age (coefficient: 4.327, p < 0.001), decreased BMI (coefficient: 1.762, p < 0.001), and the development of abnormal M line (coefficient: 0.132, p = 0.02), H line (coefficient: 0.129 p = 0.045), and eLASV (coefficient: 4.486, p < 0.001). After adjusting for age and BMI, differences remained significant for M line (coefficient: 0.125, p = 0.047), and eLASV (coefficient: 3.643, p < 0.001).
In multiple regression analysis increase in eLASV was significantly associated with advancing age (coefficient: 0.265, p = 0.01), decreasing PMI (coefficient: 2.984, p = 0.01), and increasing parity (coefficient: 3.248, p = 0.01), but not BMI (coefficient: 0.090, p = 0.74).