Gynaeco-Obstetric Background and vaginal delivery instrumentation as predisposing factors for urethral prolapse in postmenopausal women

Noya-Mourullo A1, Rocha-de-Lossada A1, García-Gómez F1, Urrea-Serna C1, Arqued-Sanagustín J1, Gómez-Aristizábal A1, Coderque-Mejía M1, Heredero-Zorzo Ó1, Herrero-Polo M1, Tinajas-Saldaña A1, Palacios-Hernández A1, Martín-Parada A1, Eguíluz-Lumbreras P1, Hernández-Sánchez T1, Herrera-Puerto J1, Cañada-de-Arriba F1, García-García J1, Nuñez-Otero J2, Márquez-Sánchez G3, Flores-Fraile J3, Márquez-Sánchez M3, Padilla-Fernández B4, Castro-Díaz D4, Lorenzo-Gómez M1

Research Type

Clinical

Abstract Category

Urethra Male / Female

Abstract 530
Open Discussion ePosters
Scientific Open Discussion Session 34
Saturday 10th September 2022
13:15 - 13:20 (ePoster Station 2)
Exhibition Hall
Female Pelvic Organ Prolapse Retrospective Study
1. Hospital Universitario de Salamanca, 2. Complexo Hospitalario Universitario De Santiago, 3. Universidad de Salamanca, 4. Universidad de La Laguna
In-Person
Presenter
Links

Poster

Abstract

Hypothesis / aims of study
The aim of this study is to know the relationship between the gynaeco-obstetric background and urethral prolapse (as a possible origin or risk factor).
Study design, materials and methods
Retrospective observational study including all women who have undergone surgery for urethral prolapse in a university hospital between 17/10/2000 and 15/04/2021. 
Inclusion criteria: female adult patients (18 years or older). 
Variables: Age at surgery, body mass index (BMI), concomitant disorders and drug treatment, toxic habits, medical and surgical background, gynaeco-obstetric history; health status defined by the American Society of Anaesthesiologists (ASA) Physical Status Classification System, reason for consultation, time between diagnosis and surgery, functional results: SF-36 quality of life questionnaire, urinary incontinence, bulge sensation, bleeding, dyspareunia, urinary urgency and/or frequency.
Results
Seventeen patients were identified. Median age was 71.00 years (range 57-81). Mean BMI was 23.67 kg/m2 (SD 2.28, range 20.81-29.38). Median number of deliveries was 2.00 (SD 1.10, range 0-4): 58.82% of patients had eutocic deliveries (p=0.0006), 17.65% had dystocic deliveries requiring vaginal instrumentation (p=1.0) and 17.65% have had a caesarean section (p=1.0). A history of hysterectomy was found in 17.65% of patients (p= 0.51). 
In patients with previous vaginal instrumentation, no differences were found in the incidence of urethral prolapse between patients consulting because of vaginal bulge sensation and other reasons for consultation; however, it was three times more frequent to have both hysterectomy and vaginal bulge sensation (33.33%) than hysterectomy without bulge sensation (9.99%), although no statistically significant differences were found (p=0.5147). 
In logistic regression analysis, the greater the number of deliveries, the greater the probability of presenting urethral bulge (p=0.032). Correlation between cystocele and number of deliveries was studied, and a negative regression coefficient was found (-0.455); that means that patients without cystocele had a greater number of deliveries (p= 0.003).
Interpretation of results
Urethral prolapse is defined as the drop and eversion of the urethral mucosa, it affects postmenopausal women and prepuberal girls. its aetiology is attributed to several factors, including genetic and environmental predisposition, as well as recurrent urinary tract infections, abdominal trauma, burns, malnutrition, sexual abuse, oestrogenic deficiency, oophorectomy, chemotherapy, asthma and high airway infections, hernias, and preterm labour.
It seems controversial that vaginal instrumentation during labour or pelvic surgeries affecting the ligaments involved in pelvic organ support don’t have an influence in the development of urethral prolapse, but the lack of statistically significant differences may be explained by the sample size in a low prevalence disorder.
Concluding message
A medical background with hysterectomy, cystocele or caesarean sections doesn’t seem to be linked with urethral prolapse. Although a greater number of deliveries was associated more frequently with the reason for consultation of vaginal bulge sensation in patients with urethral prolapse, we cannot affirm that pregnancy and deliveries are risk factors for the development of urethral prolapse.
Disclosures
Funding None Clinical Trial No Subjects Human Ethics Committee CEIM del Área de Salud de Salamanca Helsinki Yes Informed Consent Yes
05/11/2024 23:12:14