A total of 14,365 adults (7,023 men, 7,342 women, mean age 52.6 years) aged 20-85 years were included in the study. There were 1,873 CVD cases (13%). Nocturia occurred in 4,727 individuals (32.9%), and the prevalence according to sex was 30.6% in men and 35.2% in women. The presence of CVD was more common in the elderly, men, those with higher BMI, smokers, and those with diabetes, hypertension, and hyperlipidemia. There was also a significantly higher prevalence of nocturia in the participants with CVD. In the multivariate analysis, the odds ratios (ORs) of mild and severe nocturia for CVD were 1.259 (95% CI, 1.12-1.417, p <0.001) and 1.996 (95% CI, 1.627-2.449, p <0.001), respectively. Taking into account the heterogeneity of participants with CVD, additional analysis was performed using 1:1 PSM. Although there was little heterogeneity of other confounding variables due to CVD, the ORs of mild and severe nocturia were 1.221 (95% CI, 1.064-1.401, p = 0.004) and 1.833 (95% CI, 1.431-2.347, p <0.001), respectively, showing maintained statistical significance.