The classification of cases was TAM 51cases, NAF 70 cases, and SIL 283 cases. Background of alpha-AR blockage use case was shown median (range), TAM was age 78 (54-97), PSA 4.1 (0.5-21.1) ng/mL, PV 53.3 (22.1-149.0) mL, PVR 19.9 (0-238.0) mL, NAF was 77 (56-93), 4.1 (0.2-46.3) ng/mL, 57.5 (24.2-181.0) mL, 26.0 (0-249.0) mL, and SIL was 75 (53-96), 5.1 (0.7-28.9) ng/mL, 62.8 (26.0-245.3) mL, 86.1 (0-479.0) mL. Compared with TAM and NAF, SIL significantly increased PVR (p<0.01). The rate of change of serum PSA in each groups were significantly decreased (p<0.001) at 6,12,24, and 36M, respectively. Compared with TAM, NAF and SIL were significantly decreased (p<0.05) at 12M (-44.9±23.8, -58.2±15.2, and -55.9±18.0%) (Fig. 1). The rate of change of PV in each groups were significantly decreased (p<0.001) at 6,12,24, and 36M, respectively. Compared with NAF and SIL, TAM was significantly decreased (p<0.05) at 3M (-21.2±10.6, -14.9±13.5, and -16.1±11.4%) and 6M (-26.9±12.4, -19.8±12.3, and -20.2±12.1%) (Fig. 2). PVR in each groups were discussed the change from the baseline. TAM was significantly decreased at 3 (p<0.01),6 (p<0.05),12 (p<0.01), and 36M (p<0.05), and SIL was significantly decreased at 3,6,12,24, and 36M (p<0.001) respectively. The duration of each groups for up to 3 years were 19.4±12.9, 22.5±13.2, and 24.5±13.1M. Compared with TAM, SIL was significantly longer (p<0.05).