Of the 974 men, 12 men were excluded for analysis due to the presence of prostate cancer or missing data. The remaining 962 men are stratified into groups according to their status of AUR and mortality within the study period for comparison. Baseline characteristics, occurrence of AUR, need of prostate surgery for LUTS/AUR, mortality status, time spanning from the first visit to the day of prostate surgery, length of follow up, all-causes mortality rate and age-specific rate of AUR are tabulated in the table attached.
Incident AUR increases with age {Rate ratio (RR) >80yo/60-70yo = 2.50; 95%CI: 1.34-4.55, whereas RR >80yo/<60yo = 2.86; 95%CI: 1.40-5.87}. Subjects who develop AUR within the study period also have higher overall all-causes mortality (Rate ratio : 2.20 95%CI: 1.22- 3.78) in the cohort.
Men being able to survive and/or evade AUR across the study statistically differ from their contrasting subjects by their age, weight, systolic blood pressure, pulse pressure, medical background, LUTS quantification by IPSS, episodes of nocturia (>=3 per night), parameters of uroflowmetry, prostate size and glomerular filtration rate by Modification of Diet in Renal Disease (e-GFR MDRD). Of note, the difference is most drastic in the volume of voided urine at baseline uroflowmetry (its magnitude differed by 40-50%). ROC analysis showed that its value of the area under curve (AUC) to predict AUR and all-causes mortality are 0.671 (95%CI: 0.622-0.720) (p < 0.001) and 0.704 ( 95% CI: 0.649-0.760) (p<0.001) respectively. Cut-off values of 125 ml, 175 ml, and 250 ml of voided volume are taken respectively for survival analysis to assess their ability to predict future AUR and/or all-causes mortality. The K-M analyses are depicted in the figure attached. Cut-off value of 250 ml is taken as <5% of men acquiring such a characteristic will develop AUR in ~ 5 years (Log-rank p=0.002).
Cox regression proportional hazard analysis showed that only age>67 (B= -0.474, SE= 0.212, Wald statistics= 5.014, p=0.025) and volume of voided urine <250ml ( B= -1.390, SE=0.286, Wald statistics= 23.658, p<0.001) are the independent variables determining AUR, whereas for all-causes mortality, their values for B, SE, Wald statistics and p-values are: -1.234, 0.269, 21.102, <0.001 for age >67y.o. ; -0.913, 0.284,10.331, 0.001 for voided volume <250ml and -0.448, 0.239, 3.505, 0.061 for DM, respectively.